In female mammals, mechanisms have been developed, throughout evolution, to integrate
environmental, nutritional and hormonal cues in order to guarantee reproduction in …

Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in
combination with other drugs, restores the ovarian function in women with polycystic ovary …

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of
increasing significance due to increased use of expanded criteria livers for transplantation …

Adipose tissue produces factors, including adipokines, cytokines and chemokines which,
when released, systemically exert endocrine effects on multiple tissues thereby affecting …

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are
impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin …

Pharmaceuticals and personal care products (PPCPs) have been widely distributed and
posed ecotoxicological risks in the aquatic environment. This study aims to evaluate the …

Of importance, the long-term effects of obesity are not limited to maternal health, but also
programs pathophysiology in their offspring. Children of obese gravida are at increased risk …

Environmental estrogens, including bisphenol A (BPA) and 17β-estradiol (E2), which are
widely used in industries and medicine, pose a severe ecological threat to fish due to …

AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism
through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic …

Type 2 diabetes mellitus impairs reproductive functions in men, and important tasks are
deciphering the mechanisms of testicular dysfunctions in diabetes and the search of …