For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that
is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has …

Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Monocyte chemoattractant protein-1 and the kidney : Current Opinion in Nephrology and
Hypertension Monocyte chemoattractant protein-1 and the kidney : Current Opinion in …

Neutrophil migration to injured and pathogen-infected tissues is a fundamental component
of innate immunity. An array of cellular and molecular events mediate this response to …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Effector T cells leave the lymph nodes armed with specialized functional attributes. Their
antigenic targets may be located anywhere in the body, posing the ultimate challenge: how …

Heparan sulfate is found on the surface of most cell types, as well as in basement
membranes and extracellular matrices. Its strong anionic properties and highly variable …

L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating
leukocytes, including neutrophils. Engagement of L-selectin with endothelial-derived ligands …