Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Metabolic engineering of Escherichia coli for natural product biosynthesis

D Yang, SY Park, YS Park, H Eun, SY Lee - Trends in Biotechnology, 2020 - cell.com
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

RAVEN 2.0: A versatile toolbox for metabolic network reconstruction and a case study on Streptomyces coelicolor

H Wang, S Marcišauskas, BJ Sánchez… - PLoS computational …, 2018 - journals.plos.org
RAVEN is a commonly used MATLAB toolbox for genome-scale metabolic model (GEM)
reconstruction, curation and constraint-based modelling and simulation. Here we present …

[HTML][HTML] Bacteria as an alternate biofactory for carotenoid production: A review of its applications, opportunities and challenges

S Ram, M Mitra, F Shah, SR Tirkey, S Mishra - Journal of Functional Foods, 2020 - Elsevier
Carotenoid has gained a reputation amongst researchers for its robust antioxidant
capabilities. This review reasons the inevitability of carotenoid for a larger role than just …

Metabolic engineering of Escherichia coli using CRISPR–Cas9 meditated genome editing

Y Li, Z Lin, C Huang, Y Zhang, Z Wang, Y Tang… - Metabolic …, 2015 - Elsevier
Engineering cellular metabolism for improved production of valuable chemicals requires
extensive modulation of bacterial genome to explore complex genetic spaces. Here, we …

Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering

KR Choi, WD Jang, D Yang, JS Cho, D Park… - Trends in …, 2019 - cell.com
Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0

Y Chen, J Gustafsson, A Tafur Rangel, M Anton… - Nature …, 2024 - nature.com
Genome-scale metabolic models (GEMs) are computational representations that enable
mathematical exploration of metabolic behaviors within cellular and environmental …

Metabolic engineering of Escherichia coli with electron channelling for the production of natural products

SY Park, H Eun, MH Lee, SY Lee - Nature Catalysis, 2022 - nature.com
The biosynthesis of natural products often requires eukaryotic cytochrome P450s (P450s) in
combination with P450 reductase, in physical proximity, to perform electron-transfer …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …