BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological
changes occur during cellular senescence, including the formation of a unique cellular …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

Noncoding RNAs (ncRNA) participate in epigenetic regulation but are poorly understood.
Here we characterize the transcriptional landscape of the four human HOX loci at five base …

Epigenetic signals are responsible for the establishment, maintenance, and reversal of
metastable transcriptional states that are fundamental for the cell's ability to “remember” past …

Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the
methylation of lysine 27 on histone H3 (H3K27me). This histone modification is a feature of …

This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …