Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous
membraneless organelles with essential cellular function. However, aberrant phase …

The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Malignancies can compromise innate immunity, but the mechanisms of this are largely
unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers were able to …

The nucleus is an essential organelle for the function of cells. It holds most of the genetic
material and plays a crucial role in the regulation of cell growth and proliferation. Since …

Proteins in the karyopherin-β family mediate the majority of macromolecular transport
between the nucleus and the cytoplasm. Eleven of the 19 known human karyopherin-βs and …

Bidirectional transport of macromolecules across the nuclear envelope is a hallmark of
eukaryotic cells, in which the genetic material is compartmentalized inside the nucleus. The …