Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome

J Wang, D Wu, H Guo, M Li - Life sciences, 2019 - Elsevier
Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive
endocrine diseases, which has a variety of effects on a woman's health. Because of the …

Resistance to the insulin and elevated level of androgen: A major cause of polycystic ovary syndrome

H Ding, J Zhang, F Zhang, S Zhang, X Chen… - Frontiers in …, 2021 - frontiersin.org
PCOS has a wide range of negative impacts on women's health and is one of the most
frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and …

Diagnosis and management of polycystic ovary syndrome in adolescents

M Trent, CM Gordon - Pediatrics, 2020 - publications.aap.org
Polycystic ovary syndrome (PCOS) is a common female reproductive disorder that often
manifests during adolescence and is associated with disruptions in health-related quality of …

Are the antidepressant effects of insulin-sensitizing medications related to improvements in metabolic markers?

T Toba-Oluboka, K Vochosková, T Hajek - Translational Psychiatry, 2022 - nature.com
Insulin-sensitizing medications were originally used in psychiatric practice to treat weight
gain and other metabolic side effects that accompany the use of mood stabilizers …

Metformin improves the depression symptoms of women with polycystic ovary syndrome in a lifestyle modification program

F AlHussain, Y AlRuthia, H Al-Mandeel… - Patient preference …, 2020 - Taylor & Francis
Background Metformin is commonly prescribed to manage polycystic ovary syndrome
(PCOS), which is one of the most common endocrine disorders among women of …

Metformin: A prospective alternative for the treatment of chronic pain

GDC Baeza-Flores, CG Guzmán-Priego… - Frontiers in …, 2020 - frontiersin.org
Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug
has been used for 60 years as a highly effective antihyperglycemic agent. The search for the …

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions

SAH Dass, K McCracken, I Pokhvisneva, LM Chen… - …, 2019 - thelancet.com
Background Activation of brain insulin receptors modulates reward sensitivity, inhibitory
control and memory. Variations in the functioning of this mechanism likely associate with …

Metformin: a growing journey from glycemic control to the treatment of Alzheimer's disease and depression

M El Massry, LM Alaeddine, L Ali… - Current Medicinal …, 2021 - ingentaconnect.com
Metabolic stress, transduced as an altered cellular redox and energy status, presents as the
main culprit in many diseases, including diabetes. However, its role in the pathology of …

Disrupting the mood and obesity cycle: the potential role of metformin

SN Doan, SK Patel, B Xie, RA Nelson, LD Yee - Obesities, 2023 - mdpi.com
Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised
metabolic health and psychological functioning worsen clinical outcomes, diminish quality of …

Association between insulin resistance and abnormal menstrual cycle in Chinese patients with polycystic ovary syndrome

J Niu, M Lu, B Liu - Journal of Ovarian Research, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is a common reproductive endocrine
disorder, which is characterized by insulin resistance (IR) and menstrual cycle disorders. IR …