Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

Summary European Respiratory Society guidelines for the management of adult
bronchiectasis highlight the paucity of treatment options available for patients with this …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

Neutrophil serine proteases (NSPs), such as neutrophil elastase (NE), are activated by
dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. High NSP levels can be …

Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of
neutrophil serine proteases, and participates in the inflammation and immune regulation …

Airway inflammation plays a central role in bronchiectasis. Protease–antiprotease balance is
crucial in bronchiectasis pathophysiology and increased presence of unopposed proteases …

Brensocatib is a novel, oral, selective, reversible inhibitor of dipeptidyl peptidase 1 (DPP1),
which activates several neutrophil serine proteases (NSPs), including neutrophil elastase …