G-protein-coupled receptors (GPCRs) are of prime importance for cell signal transduction
mechanisms and are the target of many current and potential drugs. However, structural …

G protein-coupled receptors (GPCRS) represent a class of integral membrane proteins
involved in many biological processes and pathologies. Fifty percent of all modern drugs …

Platelet-vascular endothelial cell interactions are central to the maintenance of vascular
homeostasis. Thromboxane A 2 (TXA 2) and prostacyclin (prostaglandin (PG) I 2) are the …

The water channel protein PvTIP3; 1 (α-TIP) is a member of the Major Intrinsic Protein
membrane channel family. The in vitro activity of this aquaporin is dependent on …

Thromboxane synthase (TXAS) is one of the enzymes downstream from cyclooxygenase-2
and catalyzes the synthesis of thromboxane A2 (TXA2). TXAS was among the genes we …

With the advent of the recent determination of high-resolution crystal structures of bovine
rhodopsin and human β2 adrenergic receptor (β2AR), there are still many structure-function …

The human melatonin MT1 receptor—belonging to the large family of G protein-coupled
receptors (GPCRs)—plays a key role in circadian rhythm regulation and is notably involved …

This review will focus on some of the more recent observations concerning thromboxane A2
(TXA2) receptors (TP receptors, the official nomenclature)[1], with a major emphasis on …

Interleukin-1 is considered a central mediator of cartilage loss in osteoarthritis in several
species, however an equine recombinant form of this cytokine is not readily available for in …

ABSTRACT G protein-coupled receptors (GPCR) and cellular signaling elements are prime
targets for drug discovery. Sensitive realtime methods that expand the analytical capabilities …