Precursors of prostate cancer

DG Bostwick, L Cheng - Histopathology, 2012 - Wiley Online Library
Bostwick DG & Cheng L (2012) Histopathology 60, 4–27 Precursors of prostate cancer High‐
grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic …

Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate

R Montironi, R Mazzucchelli, A Lopez-Beltran… - Nature Clinical Practice …, 2007 - nature.com
High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of
prostatic adenocarcinoma according to virtually all available evidence. This lesion is …

Non‐steroidal antiandrogen monotherapy compared with luteinising hormone–releasing hormone agonists or surgical castration monotherapy for advanced prostate …

F Kunath, HR Grobe, G Rücker… - Cochrane Database …, 2014 - cochranelibrary.com
Background Non‐steroidal antiandrogens and castration are the main therapy options for
advanced stages of prostate cancer. However, debate regarding the value of these …

Premalignancy in prostate cancer: rethinking what we know

AM De Marzo, MC Haffner, TL Lotan… - Cancer prevention …, 2016 - AACR
High-grade prostatic intraepithelial neoplasia (PIN) has been accepted as the main
precursor lesion to invasive adenocarcinoma of the prostate, and this is likely to be the case …

Is androgen deprivation therapy effective in the treatment of sex offenders?

ME Rice, GT Harris - Psychology, Public Policy, and Law, 2011 - psycnet.apa.org
We review the effects of androgen deprivation on the sexual behavior of human males.
Although eunuchs have existed in many cultures over the last 4,000 years, there is scant …

[HTML][HTML] Chemoprevention of prostate cancer in men with high-grade prostatic intraepithelial neoplasia (HGPIN): a systematic review and adjusted indirect treatment …

K Cui, X Li, Y Du, X Tang, S Arai, Y Geng, Y Xi, H Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background High-grade prostatic intraepithelial neoplasia (HGPIN) is the precursor or
premalignant form of prostate cancer. At least 30% patients with a confirmed HGPIN will …

Drug-induced gynecomastia: A systematic review and meta-analysis of randomized clinical trials

A Trinchieri, G Perletti, V Magri… - ARCHIVIO …, 2021 - irinsubria.uninsubria.it
Objective: To review the evidence concerning treatment-related gynecomastia in patients
taking spironolactone, antiandrogens, 5 alpha-reductase inhibitors, lipid-lowering and …

Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia

JLO Merrimen, AJ Evans, JR Srigley - Pathology-Journal of the …, 2013 - journals.lww.com
There are a variety of morphological patterns and processes that have been implicated in
the pathogenesis of prostate cancer. Prostatic intraepithelial neoplasia (PIN), inflammation …

Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia

Z Zhigang, S Wenlu - International journal of cancer, 2008 - Wiley Online Library
High‐grade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target
for chemoprevention of prostate cancer (PCa). HGPIN responds to androgen ablation and …

Effects of castration on the development of prostate adenocarcinoma from its precursor HGPIN and on the occurrence of androgen-independent, poorly differentiated …

AV Bono, R Montironi, T Pannellini, F Sasso… - Prostate Cancer and …, 2008 - nature.com
Androgen ablation is thought to exert selective pressure for the development of androgen-
independent forms of prostate cancer. This study was set up to investigate the effects of …