The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …

Skin and intestinal epithelial barriers play a pivotal role in protecting underlying tissues from
harsh external environments. The protective role of these epithelia is, in part, dependent on …

Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …

E-cadherin is the core component of epithelial adherens junctions, essential for tissue
development, differentiation, and maintenance. It is also fundamental for tissue barrier …

Abstract Background Cyclosporine A (CsA) is routinely used to treat patients with steroid‐
refractory acute severe ulcerative colitis (ASUC). Here, we studied the underlying …

Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory
bowel disease (IBD). Among the various immune cells involved in IBD, neutrophils are the …

When the filtrate of the glomerulus flows through the renal tubular system, various
microscopic sediment particles, including mineral crystals, are generated. Dislodging these …

Eosinophils are currently regarded as versatile mobile cells controlling and regulating
multiple biological pathways and responses in health and disease. These cells store in their …