Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of non-cancerous liver diseases, AR …

Cancer is the second leading cause of death globally and its incidence and mortality are
rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells …

To understand the underlying mechanism (s) for the effect of exercise at different intensities
on T cell and DNA vaccination responses, we treated mice in a training protocol with regular …

Androgen/androgen receptor (AR) signaling plays important roles in normal liver function
and in progression of liver diseases. In studies of noncancerous liver diseases, AR knockout …

Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address
urgent clinical needs—is a widely overlooked opportunity. Off-label prescribing (ie, for a …

Histamine exerts potent modulatory impacts on the cells of innate-[including neutrophils,
monocytes, macrophages, dendritic cells (DCs), natural killer (NK) cells and NKT cells] and …

Astragalus polysaccharides (APS), extracted from the root of Astragalus membranaceus, a
traditional Chinese medicinal herb, have extensive pharmacological and strong …

Background Recent data suggest that acid suppressive medications may alter factors central
to the pathophysiology of inflammatory bowel diseases (IBD), whether through shifts in the …

Recent advances in understanding the physiological role of mast cells (MCs) points to an
important regulatory role for these cells in adaptive immunity. MCs express a diverse array of …

A diversity of immune mechanisms have evolved to protect normal tissues from infection, but
from immune damage too. Innate cells, as well as adaptive cells, are critical contributors to …