Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …

INTRODUCTION Extensive tumor sequencing efforts have transformed the way in which
cancer driver genes are identified. Appropriate statistical modeling is crucial for …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI
study using whole exome sequencing. Here we identify mutations induced as a …

APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic
factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC …

Breast tumors often display extreme genetic heterogeneity characterized by hundreds of
gross chromosomal aberrations and tens of thousands of somatic mutations. Tumor …

Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …

APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA
damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …