RNA-induced silencing complex recognizes its target mRNA through Watson-Crick
complementarity of its 5′-end to the 3′-UTR of its target (Figure 1B). Whereas in plants …

MicroRNAs (miRNAs) are endogenous small noncoding~ 22-nt RNAs, which have been
reported to play a crucial role in maintaining bone development and metabolism …

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late
diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal …

The Ras-responsive element binding protein 1 (RREB1) is a member of zinc finger
transcription factors, which is widely involved in biological processes including cell …

Alternative polyadenylation (APA) is a gene regulatory process that dictates mRNA 3′-UTR
length, resulting in changes in mRNA stability and localization. APA is frequently disrupted …

Immunotherapy, designed to exploit the functions of the host immune system against tumors,
has shown considerable potential against several malignancies. However, the utility of …

Pancreatic cancer has become the fourth leading cause of cancer death in the last two
decades. Only 3%-15% of patients diagnosed with pancreatic cancer had 5 year survival …

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal
prognosis for which new therapeutic strategies are desperately needed. Non-coding RNAs …

Non-coding RNAs (ncRNAs) are reported to be expressed in human cancers, including
pancreatic ductal adenocarcinoma (PDAC). These ncRNAs affect the growth, migration and …

MicroRNAs have emerged as fundamental regulators in gene expression through silencing
gene expression at the post-transcriptional and translational levels. In this study, miR-143 …