Miniaturization can expand the capability of existing bioassays, separation technologies and
chemical synthesis techniques. Although a reduction in size to the micrometre scale will …

DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

We describe genome mapping on nanochannel arrays. In this approach, specific sequence
motifs in single DNA molecules are fluorescently labeled, and the DNA molecules are …

The area of micro total analysis systems (μTAS), also called “lab on a chip”, miniaturized or
microfluidic analysis systems, is a rapidly developing field. During the last several years, we …

The present methods are exemplified by a process in which maternal blood containing fetal
DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per …

Recent developments in micro-and nanotechnologies made possible the fabrication of
devices integrating a deterministic network of nanochannels, ie, with at least one dimension …

Disclosed is a method to achieve digital quantification of DNA (ie, counting differences
between identical sequences) using direct shotgun sequencing followed by mapping to the …

Molecular confinement offers new routes for arraying large DNA molecules, enabling single-
molecule schemes aimed at the acquisition of sequence information. Such schemes can …

The present methods are exemplified by a process in which maternal blood containing fetal
DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per …

Here we explore the potential power of denaturation mapping as a single-molecule
technique. By partially denaturing YOYO®-1-labeled DNA in nanofluidic channels with a …