Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

The role of gut microbiota in an ischemic stroke

R Pluta, S Januszewski, SJ Czuczwar - International journal of molecular …, 2021 - mdpi.com
The intestinal microbiome, the largest reservoir of microorganisms in the human body, plays
an important role in neurological development and aging as well as in brain disorders such …

Nanoparticles for brain drug delivery

M Masserini - International Scholarly Research Notices, 2013 - Wiley Online Library
The central nervous system, one of the most delicate microenvironments of the body, is
protected by the blood‐brain barrier (BBB) regulating its homeostasis. BBB is a highly …

Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?

R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

Gut microbes in cerebrovascular diseases: gut flora imbalance, potential impact mechanisms and promising treatment strategies

X Zou, L Wang, L Xiao, S Wang, L Zhang - Frontiers in immunology, 2022 - frontiersin.org
The high morbidity, mortality, and disability rates associated with cerebrovascular disease
(CeVD) pose a severe danger to human health. Gut bacteria significantly affect the onset …

[HTML][HTML] Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival

L Radenovic, M Nenadic, M Ułamek-Kozioł… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
The present study was designed to follow neuroinflammation after ischemic brain injury in
the long-term survival rat model. Immunohistochemistry was performed 2 years after 10 min …

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

R Niranjan - Neurochemistry international, 2018 - Elsevier
Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

Brain ischemia as a prelude to Alzheimer's disease

R Pluta, S Januszewski, SJ Czuczwar - Frontiers in Aging …, 2021 - frontiersin.org
Transient ischemic brain injury causes massive neuronal death in the hippocampus of both
humans and animals. This was accompanied by progressive atrophy of the hippocampus …

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

A Kantarci, N Aytan, I Palaska, D Stephens… - Experimental …, 2018 - Elsevier
Dysfunction in the resolution of inflammation may play a key role in Alzheimer's disease
(AD). In this study, we found that the levels of specialized pro-resolving lipid mediators …

Post-ischemic brain neurodegeneration in the form of Alzheimer's disease proteinopathy: Possible therapeutic role of curcumin

R Pluta, W Furmaga-Jabłońska, S Januszewski… - Nutrients, 2022 - mdpi.com
For thousands of years, mankind has been using plant extracts or plants themselves as
medicinal herbs. Currently, there is a great deal of public interest in naturally occurring …