Once and only once: mechanisms of centriole duplication and their deregulation in disease

EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

The centrosome and its duplication cycle

J Fu, IM Hagan, DM Glover - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization

V Mennella, B Keszthelyi, KL McDonald, B Chhun… - Nature cell …, 2012 - nature.com
As the main microtubule-organizing centre in animal cells, the centrosome has a
fundamental role in cell function. Surrounding the centrioles, the pericentriolar material …

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

KF Sonnen, L Schermelleh, H Leonhardt… - Biology …, 2012 - journals.biologists.com
Centrioles are essential for the formation of cilia and flagella. They also form the core of the
centrosome, which organizes microtubule arrays important for cell shape, polarity, motility …

[HTML][HTML] Structural basis of the 9-fold symmetry of centrioles

D Kitagawa, I Vakonakis, N Olieric, M Hilbert, D Keller… - Cell, 2011 - cell.com
The centriole, and the related basal body, is an ancient organelle characterized by a
universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes …

A helical inner scaffold provides a structural basis for centriole cohesion

M Le Guennec, N Klena, D Gambarotto, MH Laporte… - Science …, 2020 - science.org
The ninefold radial arrangement of microtubule triplets (MTTs) is the hallmark of the
centriole, a conserved organelle crucial for the formation of centrosomes and cilia. Although …

Towards a molecular architecture of centriole assembly

P Gönczy - Nature reviews Molecular cell biology, 2012 - nature.com
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …

Structures of SAS-6 suggest its organization in centrioles

M van Breugel, M Hirono, A Andreeva, H Yanagisawa… - Science, 2011 - science.org
Centrioles are cylindrical, ninefold symmetrical structures with peripheral triplet microtubules
strictly required to template cilia and flagella. The highly conserved protein SAS-6 …

The centriole duplication cycle

EN Fırat-Karalar, T Stearns - … Transactions of the Royal …, 2014 - royalsocietypublishing.org
Centrosomes are the main microtubule-organizing centre of animal cells and are important
for many critical cellular and developmental processes from cell polarization to cell division …

[HTML][HTML] Building the centriole

J Azimzadeh, WF Marshall - Current Biology, 2010 - cell.com
Centrioles are conserved microtubule-based organelles that lie at the core of the animal
centrosome and play a crucial role in nucleating the formation of cilia and flagella in most …