Fetal neuroprotection by magnesium sulfate: from translational research to clinical application

C Chollat, L Sentilhes, S Marret - Frontiers in neurology, 2018 - frontiersin.org
Despite improvements in perinatal care, preterm birth still occurs regularly and the
associated brain injury and adverse neurological outcomes remain a persistent challenge …

Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

C Chollat, S Marret - Neural regeneration research, 2018 - journals.lww.com
Antenatal administration of magnesium sulfate is an important part of the neuroprotective
strategy for preterm infants. Strong evidence from five randomized controlled trials and five …

Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection

G Koning, AL Leverin, S Nair… - Journal of Cerebral …, 2019 - journals.sagepub.com
Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in
their offspring but the mechanism behind this protection is unclear, limiting its effective, safe …

Magnesium sulphate reduces tertiary gliosis but does not improve EEG recovery or white or grey matter cell survival after asphyxia in preterm fetal sheep

R Galinsky, SK Dhillon, SB Kelly… - The Journal of …, 2023 - Wiley Online Library
Maternal magnesium sulphate (MgSO4) treatment is widely recommended before preterm
birth for neuroprotection. However, this is controversial because there is limited evidence …

Serum magnesium levels in preterm infants are higher than adult levels: a systematic literature review and meta-analysis

J Rigo, C Pieltain, V Christmann, F Bonsante, SJ Moltu… - Nutrients, 2017 - mdpi.com
Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of
biomacromolecules, bone matrix development, energy production, as well as heart, nerve …

Time and sex dependent effects of magnesium sulphate on post‐asphyxial seizures in preterm fetal sheep

L Bennet, R Galinsky, V Draghi, CA Lear… - The Journal of …, 2018 - Wiley Online Library
Key points We evaluated the effect of magnesium sulphate (MgSO4) on seizures induced by
asphyxia in preterm fetal sheep. MgSO4 did not prevent seizures, but significantly reduced …

Magnesium sulfate reduces EEG activity but is not neuroprotective after asphyxia in preterm fetal sheep

R Galinsky, V Draghi, G Wassink… - Journal of Cerebral …, 2017 - journals.sagepub.com
Magnesium sulfate is now widely recommended for neuroprotection for preterm birth;
however, this has been controversial because there is little evidence that magnesium sulfate …

Alternative regimens of magnesium sulfate for treatment of preeclampsia and eclampsia: a systematic review of non‐randomized studies

JJ Pratt, PS Niedle, JP Vogel… - Acta obstetricia et …, 2016 - Wiley Online Library
Introduction The optimal dosing regimen of magnesium sulfate for treating preeclampsia and
eclampsia is unclear. Evidence from the Cochrane review of randomized controlled trials …

Magnesium sulphate and cardiovascular and cerebrovascular adaptations to asphyxia in preterm fetal sheep

R Galinsky, JO Davidson, PP Drury… - The Journal of …, 2016 - Wiley Online Library
Key points Magnesium sulphate is the recommended treatment for pre‐eclampsia and is
now widely recommended for perinatal neuroprotection. MgSO4 has vasodilatory and …

[HTML][HTML] Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia

G Koning, E Lyngfelt, P Svedin, AL Leverin… - International Journal of …, 2018 - Elsevier
Background Brain injury in preterm infants represents a substantial clinical problem
associated with development of motor impairment, cognitive deficits and psychiatric …