Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Parathyroid hormone (PTH) is an 84-amino-acid peptide hormone that is secreted by the
parathyroid gland. It has different administration modes in bone tissue through which it …

Background Osteoblast differentiation is a vital process for fracture healing, and exosomes
are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have
preserved in evolution sufficient identities in their amino-terminal domains to share …

Osteoporosis is a major public health problem. Currently, there are no orally available
therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates …

The renal actions of parathyroid hormone (PTH) promote 1, 25-vitamin D generation;
however, the signaling mechanisms that control PTH-dependent vitamin D activation remain …

Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …

Tooth eruption is a unique biological process by which highly mineralized tissues emerge
into the outer world, and it occurs concomitantly with tooth root formation. These 2 processes …

Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones,
including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor …