Recent advances in the Friedlander reaction
J Marco-Contelles, E Pérez-Mayoral, A Samadi… - Chemical …, 2009 - ACS Publications
The quinoline ring system1-5 is present in a number of natural6 and synthetic products often
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
Acetylcholinesterase: a versatile template to coin potent modulators of multiple therapeutic targets
FJ Luque, D Muñoz-Torrero - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The enzyme acetylcholinesterase (AChE) hydrolyzes the neurotransmitter
acetylcholine (ACh) at cholinergic synapses of the peripheral and central nervous system …
acetylcholine (ACh) at cholinergic synapses of the peripheral and central nervous system …
Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds
P Camps, X Formosa, C Galdeano… - Journal of medicinal …, 2009 - ACS Publications
Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been
designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase …
designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase …
Discovery of multitarget-directed ligands against Alzheimer's disease through systematic prediction of chemical–protein interactions
To determine chemical–protein interactions (CPI) is costly, time-consuming, and labor-
intensive. In silico prediction of CPI can facilitate the target identification and drug discovery …
intensive. In silico prediction of CPI can facilitate the target identification and drug discovery …
Identifying possible AChE inhibitors from drug-like molecules via machine learning and experimental studies
Acetylcholinesterase (AChE) is one of the most important drug targets for Alzheimer's
disease (AD) treatment. In this work, a machine learning model was trained to rapidly and …
disease (AD) treatment. In this work, a machine learning model was trained to rapidly and …
[HTML][HTML] Discovery of novel acetylcholinesterase inhibitors as potential candidates for the treatment of Alzheimer's disease
Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to
acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked …
acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked …
Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents
C Galdeano, E Viayna, P Arroyo… - Current …, 2010 - ingentaconnect.com
Dual binding site acetylcholinesterase inhibitors have recently emerged as a new class of
anti-Alzheimer agents with potential to positively modify the course of the disease. These …
anti-Alzheimer agents with potential to positively modify the course of the disease. These …
Protocol for fast screening of multi-target drug candidates: Application to Alzheimer's disease
The treatment of many diseases may require drugs that are capable to attack multiple targets
simultaneously. Obviously, the virtual screening of multi-target drug candidates is much …
simultaneously. Obviously, the virtual screening of multi-target drug candidates is much …
Homo-and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors
F Leonetti, M Catto, O Nicolotti, L Pisani… - Bioorganic & Medicinal …, 2008 - Elsevier
A number of mono-and bis-quaternary ammonium salts, containing edrophonium-like and
coumarin moieties tethered by an appropriate linker, proved to be highly potent and …
coumarin moieties tethered by an appropriate linker, proved to be highly potent and …
Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
New series of Huprine (12-amino-6, 7, 10, 11-tetrahydro-7, 11-methanocycloocta [b]
quinolines) derivatives have been synthesized and their inhibiting activities toward …
quinolines) derivatives have been synthesized and their inhibiting activities toward …