Nucleic acid-based molecular computation heads towards cellular applications

L Chen, W Chen, G Liu, J Li, C Lu, J Li, W Tan… - Chemical Society …, 2021 - pubs.rsc.org
Nucleic acids, with the advantages of programmability and biocompatibility, have been
widely used to design different kinds of novel biocomputing devices. Recently, nucleic acid …

Development of general methods for detection of virus by engineering fluorescent silver nanoclusters

D Li, H Chen, X Gao, X Mei, L Yang - ACS sensors, 2021 - ACS Publications
Viruses have caused significant damage to the world. Effective detection is required to
relieve the impact of viral infections. A biomolecule can be used as a template such as …

DM3Loc: multi-label mRNA subcellular localization prediction and analysis based on multi-head self-attention mechanism

D Wang, Z Zhang, Y Jiang, Z Mao, D Wang… - Nucleic acids …, 2021 - academic.oup.com
Subcellular localization of messenger RNAs (mRNAs), as a prevalent mechanism, gives
precise and efficient control for the translation process. There is mounting evidence for the …

Construction of an Autocatalytic Hybridization Assembly Circuit for Amplified In Vivo MicroRNA Imaging

H Wang, Y He, J Wei, H Wang, K Ma… - Angewandte …, 2022 - Wiley Online Library
Lowly expressed analyte in complex cytoplasmic milieu necessitates the development of
non‐enzymatic autocatalytic DNA circuits with high amplification and anti‐interference …

Closed cyclic DNA machine for sensitive logic operation and APE1 detection

Q Chai, J Chen, S Zeng, T Zhu, J Chen, C Qi, G Mao… - Small, 2023 - Wiley Online Library
DNA self‐assembly has been developed as a kind of robust signal amplification strategy, but
most of reported assembly pathways are programmed to amplify signal in one direction …

Hierarchical hybridization chain reaction for amplified signal output and cascade DNA logic circuits

WY Lv, CH Li, YF Li, SJ Zhen, CZ Huang - Analytical Chemistry, 2021 - ACS Publications
In this work, we propose a three-layer hierarchical hybridization chain reaction (3L hHCR)
composed of 1stHCR, 2ndHCR, and 3rdHCR to achieve robust signal amplification …

RNA Condensate as a Versatile Platform for Improving Fluorogenic RNA Aptamer Properties and Cell Imaging

R Ji, L Wang, Y Shang, S Du, Y Xiao… - Journal of the …, 2024 - ACS Publications
Fluorogenic RNA aptamers are valuable tools for cell imaging, but they still suffer from
shortcomings such as easy degradation, limited photostability, and low fluorescence …

Live-Cell Imaging of Endogenous RNA with a Genetically Encoded Fluorogenic Allosteric Aptamer

Y Peng, L Shu, X Deng, X Huang, X Mo, F Du… - Analytical …, 2023 - ACS Publications
Imaging and tracking tools for natural cellular RNA with improved biocompatibility,
specificity, and sensitivity are critical to understanding RNA function and providing insights …

Cotranscriptionally encoded RNA strand displacement circuits

SW Schaffter, EA Strychalski - Science Advances, 2022 - science.org
Engineered molecular circuits that process information in biological systems could address
emerging human health and biomanufacturing needs. However, such circuits can be difficult …

In Situ Self‐Assembly of Fluorogenic RNA Nanozipper Enables Real‐Time Imaging of Single Viral mRNA Translation

YP Zhang, ZG Wang, YF Tian, LH Jiang… - Angewandte Chemie …, 2023 - Wiley Online Library
Real‐time visualization of individual viral mRNA translation activities in live cells is essential
to obtain critical details of viral mRNA dynamics and to detect its transient responses to …