Species of the Diospyros L. genus (Ebenaceae family) have been largely used in traditional
medicine for the treatment of several diseases, especially infectious ones. To date, active …

The review describes the use of glyceraldehyde 3-phosphate dehydrogenase (GAPDH)
inhibitors to study the enzyme and to suppress its activity in various cell types. The main …

Ruthenium-catalysis enabled the C-5 selective C–H oxygenation of naphthoquinones, and
also sets the stage for the site-selective introduction of a hydroxyl group into …

A series of coumarin derivatives bearing a pyrrole scaffold were designed, prepared, and
assessed for their in vitro antifungal activities against six phytopathogenic fungi. The …

Leishmania and Trypanosoma parasites are responsible for the challenging neglected
tropical diseases leishmaniases, Chagas disease, and human African trypanosomiasis …

Abstract Diospyros species (DS),“Ebenaceae,” were known for their therapeutic uses in folk
medicine since days of yore. Thereafter, scientific evidence related their health benefits to a …

Herein, the design and synthesis of new 2-phenyl (pyridinyl) benzimidazolequinones and
their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The …

Natural and synthetic coumarins have been described as prototypes of new drug candidates
against Chagas' disease. During a typical screening with new compounds, we observed the …

Treating methicillin-resistant Staphylococcus aureus (MRSA) infection remains one of the
most difficult challenges in clinical practice, primarily due to the resistance of MRSA to …

Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand
innovative drug development due to their impact on public health worldwide. Their cysteine …