In this year there is the 40th anniversary of the first publication of plant nitric oxide (NO)
emission by Lowell Klepper. In the decades since then numerous milestone discoveries …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

In the vascular system, endothelium-derived relaxing factor (EDRF) is the name of the local
hormone released from endothelial cells in response to vasodilators such as acetylcholine …

Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of
important physiological processes, including smooth muscle relaxation and …

Penile erection results from a complex interplay between central nervous (cerebral and
spinal) and local factors. Several aspects of these interactions have been the subject of …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Endothelial cells that make up brain capillaries and constitute the blood-brain barrier
become different from peripheral endothelial cells in response to inductive factors found in …

A soluble enzyme obtained from rat forebrain catalyzes the NADPH-dependent formation of
nitric oxide (NO) and citrulline from L-arginine. The NO formed stimulates the soluble …

The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor
has been purified from cultured and native (noncultured) bovine aortic endothelial cells …

In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …