A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
SARS-CoV-2. The scientific community has mounted a strong response by accelerating …
The nonstructural proteins directing coronavirus RNA synthesis and processing
Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …
The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2
NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
The curious case of the nidovirus exoribonuclease: its role in RNA synthesis and replication fidelity
Among RNA viruses, the order Nidovirales stands out for including viruses with the largest
RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing …
RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing …
A general two-metal-ion mechanism for catalytic RNA.
TA Steitz, JA Steitz - … of the National Academy of Sciences, 1993 - National Acad Sciences
A mechanism is proposed for the RNA-catalyzed reactions involved in RNA splicing and
RNase P hydrolysis of precursor tRNA. The mechanism postulates that chemical catalysis is …
RNase P hydrolysis of precursor tRNA. The mechanism postulates that chemical catalysis is …
Discovery of an RNA virus 3′→ 5′ exoribonuclease that is critically involved in coronavirus RNA synthesis
E Minskaia, T Hertzig, AE Gorbalenya… - Proceedings of the …, 2006 - National Acad Sciences
Replication of the giant RNA genome of severe acute respiratory syndrome (SARS)
coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated …
coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated …
DNA polymerases: structural diversity and common mechanisms
TA Steitz - Journal of Biological Chemistry, 1999 - ASBMB
Possibly the earliest enzymatic activity to appear in evolution was that of the polynucleotide
polymerases, the ability to replicate the genome accurately being a prerequisite for evolution …
polymerases, the ability to replicate the genome accurately being a prerequisite for evolution …
Structural basis for the 3′‐5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.
LS Beese, TA Steitz - The EMBO journal, 1991 - embopress.org
The refined crystal structures of the large proteolytic fragment (Klenow fragment) of
Escherichia coli DNA polymerase I and its complexes with a deoxynucleoside …
Escherichia coli DNA polymerase I and its complexes with a deoxynucleoside …
Binuclear metallohydrolases
DE Wilcox - Chemical Reviews, 1996 - ACS Publications
Metabolic and signaling biochemical pathways have numerous steps that involve the
hydrolytic cleavage of peptide or phosphate ester bonds. Although both types of bonds are …
hydrolytic cleavage of peptide or phosphate ester bonds. Although both types of bonds are …
Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificity
W Yang, JY Lee, M Nowotny - Molecular cell, 2006 - cell.com
DNA and a large proportion of RNA are antiparallel duplexes composed of an unvarying
phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How …
phosphosugar backbone surrounding uniformly stacked and highly similar base pairs. How …