Neural networks are constructed through the development of robust axonal projections from
individual neurons, which ultimately establish connections with their targets. In most …

Wiring an animal brain is a complex process involving a staggering number of cell-types
born at different times and locations in the developing brain. Incorporation of these cells into …

Axons must project to particular brain regions, contact adjacent neurons, and choose
appropriate synaptic targets to form a nervous system. Multiple mechanisms have been …

Visualizing synaptic connectivity has traditionally relied on time-consuming electron
microscopy-based imaging approaches. To scale the analysis of synaptic connectivity …

Neuronal development orchestrates the formation of an enormous number of synapses that
connect the nervous system. In developing presynapses, the core active zone structure has …

Light microscopes are the cell and developmental biologists'“best friend,” providing a means
to see structures and follow dynamics from the protein to the organism level. A huge …

The cell-adhesion molecule NEPH1 is required for maintaining the structural integrity and
function of the glomerulus in the kidneys. In the nervous system of Drosophila and C …

Analyses across imaging modalities allow the integration of complementary spatiotemporal
information about brain development, structure, and function. However, systematic atlasing …

Since the days of Ramón y Cajal, the vast diversity of neuronal and particularly dendrite
morphology has been used to catalog neurons into different classes. Dendrite morphology …

Systematic analysis of rich behavioral recordings is being used to uncover how circuits
encode complex behaviors. Here, we apply this approach to embryos. What are the first …