Tuberous sclerosis complex (TSC) is a rare genetic disorder caused by mutations in the
TSC1 or TSC2 genes, which encode proteins that antagonise the mammalian isoform of the …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Epilepsy is a long-term neurological condition that results in recurrent seizures.
Approximately 30% of patients with epilepsy have drug-resistant epilepsy (DRE). The …

Epilepsy is a widely diffused neurological disorder including a heterogeneous range of
syndromes with different aetiology, severity and prognosis. Pharmacological treatments are …

The exposure of plants to pharmaceuticals via treated wastewater irrigation and biosolid
application presents an important route of chronic exposure of crops to a wide variety of …

Purpose: Unpredictable drug efficacy and safety of combined antiepileptic therapy is a major
challenge during pharmacotherapy decisions in everyday clinical practice. The aim of this …

The review presents data from the last few years on bioanalytical methods used in
therapeutic drug monitoring (TDM) of the 1st–3rd generation and the newest antiepileptic …

Objectives This study aimed to elucidate the effects of Gentiopicroside (Gent) on
epileptogenesis and underlying mechanisms. Methods The status epilepticus (SE) model …

Risk of sudden cardiac death (SCD) increases with age, and several studies have examined
the impact of different drugs on cardiovascular function. However, few studies have …

Introduction: Dravet syndrome (severe myoclonic epilepsy in infancy) begins in the first year
of life characterized by generalized or unilateral clonic seizures that are frequently triggered …