Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis …

New data on the pharmacology of tricyclic antidepressants (TCAs), their affinities for human
cloned CNS receptors and their cytochrome P450 enzyme inhibition profiles, allow improved …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

Background After unsuccessful treatment for depression with a selective serotonin-reuptake
inhibitor (SSRI), it is not known whether switching to one antidepressant is more effective …

Prescribing of antidepressant treatment (ADT) for major depressive disorder (MDD) has
increased in quantity and popularity over the last two decades. This is likely due to the …

Context Only about 60% of adolescents with depression will show an adequate clinical
response to an initial treatment trial with a selective serotonin reuptake inhibitor (SSRI) …

A revision of the 2000 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken to …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

The Medical Management of Depression | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Both painful and nonpainful somatic symptoms essentially characterize clinical states of
depressive mood. So far, this well-established psychopathological knowledge has been …