Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Background—Intimal smooth muscle cells (SMCs) contribute to the foam cell population in
arterial plaque, and express lower levels of the cholesterol exporter ATP-binding cassette …

Epithelial-to-mesenchymal transition (EMT) is a critical event in the progression toward
cancer metastasis. The intermediate filament protein vimentin is an important marker of EMT …

Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many cancers. However, the precise molecular composition of lipids in tumors remains …

Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional
(3D) culture as spheroids, represent promising in vitro models for the study of normal and …

Background Until recently, chromosomal translocations and fusion genes have been an
underappreciated class of mutations in solid tumors. Next-generation sequencing …

cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …

Figure 1 Principal component analysis. Each dot represents one of the 5,372 samples in a
multidimensional gene expression space projected on the principal plane formed by the first …

Anti-apoptotic Bcl-2 contributes to cancer formation and progression by promoting the
survival of altered cells. Hence, it is a prime target for novel specific anti-cancer therapeutics …