COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase
mortality in patients. Platelets are fast responders to pathogen presence, alerting the …

The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …

Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability
state with high risk of life-threatening thromboembolic complications. However, the …

Viral infections are often associated with platelet activation and haemostatic complications.
In line, low platelet counts represent a hallmark for poor prognosis in many infectious …

Platelet-leukocyte crosstalk is commonly manifested by reciprocal links between thrombosis
and inflammation. Platelet thrombus acts as a reactive matrix that recruits leukocytes to the …

Abstract Coronavirus disease 2019 (COVID-19) has affected over 400 million people
worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19 …

Introduction In November 2021, the SARS-CoV-2 Omicron variant of concern has emerged
and is currently dominating the COVID-19 pandemic over the world. Omicron displays a …

Background: SARS-CoV-2 is associated with an increased risk of venous and arterial
thrombosis, but the underlying mechanism is still unclear. Methods: We performed a cross …

Sepsis is a major cause of morbidity and mortality worldwide. Sepsis-associated coagulation
disorders are involved in the pathogenesis of multiorgan failure and lead to a subsequently …

Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and
thrombosis. There are three major types of PEVs described based on their size and …