Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

The cytoskeleton comprises three polymerizing structures that have been studied for a long
time, actin microfilaments, microtubules and intermediate filaments, plus more recently …

Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that
consecutively assemble and disassemble during interphase and M phase of the cell cycle …

Mapping the intricate spatial relationships between the many different molecules inside a
cell is essential to understanding cellular functions in all their complexity. Super-resolution …

The primary cilium is a conserved microtubule-based organelle that is critical for transducing
developmental, sensory and homeostatic signaling pathways. It comprises an axoneme with …

Primary cilia transduce signals via transmembrane and membrane-associated proteins
localized to the ciliary membrane in vertebrate cells. In humans, transmembrane protein 67 …

Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and
maintenance of cilia. The dysfunction of IFT leads to ciliopathies of variable severity. Two of …

The brain is, after the adipose tissue, the organ with the greatest amount of lipids and
diversity in their composition in the human body. In neurons, lipids are involved in signaling …

Coronaviruses target ciliate cells causing the loss of cilia, acute rhinorrheas, and other
ciliopathies. The loss of ciliary function may help the virus infect, replicate, and spread …

Primary cilia are conserved sensory hubs essential for signaling transduction and embryonic
development. Ciliary dysfunction causes a variety of developmental syndromes with …