The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

Age‐related macular degeneration (AMD) is a major cause of vision impairment in the
Western World, and with the aging world population, its incidence is increasing. As of today …

Introduction: The complement system is essential for an adequate immune response. Much
attention has been given to the role of complement in disease. However, to better …

Sequence and copy number variations in the human CFHR–Factor H gene cluster
comprising the complement genes CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, and Factor H …

Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

Factor H‐related protein 1 (FHR‐1) is a member of the factor H protein family, which is
involved in regulating innate immune complement reactions. Genetic modification of the …

To discriminate between self and non-self surfaces and facilitate immune surveillance, the
complement system relies on the interplay between surface-directed activators and …

Neisseria meningitidis and Neisseria gonorrhoeae are important human pathogens that
have evolved to bind the major negative regulator of the complement system, complement …

Background The complement system is a central component of the innate immune system.
Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation …

Complement provides powerful, fast responses in the human circulation to SARS-CoV-2
(COVID-19 virus) infection of the lower respiratory tract. COVID-19 effects were investigated …