Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

O Ciofu, T Tolker-Nielsen, PØ Jensen, H Wang… - Advanced drug delivery …, 2015 - Elsevier
Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

Biofilm Formation by Staphylococcus aureus in the Specific Context of Cystic Fibrosis

V Jean-Pierre, A Boudet, P Sorlin, Q Menetrey… - International Journal of …, 2022 - mdpi.com
Staphylococcus aureus is a major human pathogen whose characteristics support its
success in various clinical settings including Cystic Fibrosis (CF). In CF, S. aureus is indeed …

Novel therapeutic strategies for treating Pseudomonas aeruginosa infection

X Shao, Y Xie, Y Zhang, J Liu, Y Ding… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Persistent infections caused by the superbug Pseudomonas aeruginosa and its
resistance to multiple antimicrobial agents are huge threats to patients with cystic fibrosis as …

Combination and nanotechnology based pharmaceutical strategies for combating respiratory bacterial biofilm infections

L Zhang, H Bera, H Wang, J Wang, Y Guo, C Shi… - International Journal of …, 2022 - Elsevier
Respiratory infections are one of the major global health problems. Among them, chronic
respiratory infections caused by biofilm formation are difficult to treat because of both drug …

The treatment of the pulmonary and extrapulmonary manifestations of cystic fibrosis

M Chin, SD Aaron, SC Bell - La Presse Médicale, 2017 - Elsevier
Cystic fibrosis (CF) is a complex multisystem disease with considerable between patient
variability in its manifestations and severity. In the past several decades, the range of …

[HTML][HTML] A critical review of definitions used to describe Pseudomonas aeruginosa microbiological status in patients with cystic fibrosis for application in clinical trials

G Taccetti, M Denton, K Hayes, D Bilton… - Journal of Cystic …, 2020 - Elsevier
Abstract Background Definition of Pseudomonas aeruginosa (Pa) microbiological status is
essential for patients' inclusion in clinical trials. The aim of this study was to agree on the …

Longitudinal monitoring of sinonasal and oral bacterial reservoirs to prevent chronic lung infection in people with cystic fibrosis

RP Mantovani, A Sandri, M Boaretti… - ERJ Open …, 2020 - Eur Respiratory Soc
Background Paranasal sinuses act as bacterial reservoirs and contribute to transmitting
bacteria to the lower airway of patients with cystic fibrosis (CF). Also, passage of bacteria …

Exploring the dynamics of mixed-species biofilms involving Candida spp. and bacteria in cystic fibrosis

K Gourari-Bouzouina, Z Boucherit-Otmani… - Archives of …, 2024 - Springer
Cystic fibrosis (CF) is an inherited disease that results from mutations in the gene
responsible for the cystic fibrosis transmembrane conductance regulator (CFTR). The …

Autofluorescence in samples obtained from chronic biofilm infections–“all that glitters is not gold”

S Eickhardt, KN Kragh, S Schrøder… - Pathogens and …, 2015 - academic.oup.com
When looking at tissue sections of ex vivo samples, autofluorescence can be a major cause
of artifacts and misinterpretations. We here reiterate evidence that autofluorescing granules …

Efficacy of Elexacaftor–Tezacaftor–Ivacaftor on chronic rhinosinusitis in cystic fibrosis

S Di Gioia, F Lucca, L Venditto, G Sandri… - American Journal of …, 2024 - Elsevier
Purpose Our work aims to add evidence on the effectiveness of Elexacaftor-Tezacaftor-
Ivacaftor on chronic rhinosinusitis in cystic fibrosis. Materials and methods We conducted an …