The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …

Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …

Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Aggregation of tau protein in the brain is associated with a class of neurodegenerative
diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by …

HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …

This review provides a broad overview of the state of research in the genetics of anxiety
disorders (AD). Genetic epidemiological studies report a moderate level of familial …

Dilated cardiomyopathies (DCM) show remarkable variability in their age of onset,
phenotypic presentation, and clinical course. Hence, disease mechanisms must exist that …

Psychosocial stress triggers a set of behavioral, neural, hormonal, and molecular responses
that can be a driving force for survival when adaptive and time-limited, but may also …

Ageing is the main risk factor for human neurological disorders. Among the diverse
molecular pathways that govern ageing, epigenetics can guide age-associated decline in …

The FK 506 binding protein 51 or FKBP5 has been implicated in the regulation of
glucocorticoid receptor (GR) sensitivity, and genetic variants in this gene have been …