Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …

Subtiligase-catalyzed peptide ligation is a powerful approach for site-specific protein
bioconjugation, synthesis and semisynthesis of proteins and peptides, and chemoproteomic …

Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is
activated by C-terminal phosphorylation. The current structural model for Akt activation by C …

γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral
membrane proteins within the lipid bilayer, an event preceded by shedding of most of the …

Highlights•Classical site-directed mutagenesis is limited in studying protein
phosphorylation.•We discuss synthetic, semisynthetic, and genetic methods to make …

Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears
to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin …

The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor
suppressor has been for a long time attributed to its lipid phosphatase activity against PI (3 …