The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized
transmembrane proteins from endosomes to the plasma membrane by linking PDZ …

The endocytic network comprises a series of interconnected tubulo-vesicular membranous
compartments that together regulate various sorting and signalling events. Although it is …

DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

Postsynaptic density 95/discs large/zonus occludens-1 (PDZ) domain–interacting motifs, in
addition to their well-established roles in protein scaffolding at the cell surface, are proposed …

The activation of mTOR signaling is essential for mechanically induced changes in skeletal
muscle mass, and previous studies have suggested that mechanical stimuli activate mTOR …

Recycling of internalized receptors from endosomal compartments is essential for the
receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer …

Inhibition of αvβ3 integrin or expression of oncogenic mutants of p53 promote invasive cell
migration by enhancing endosomal recycling of α5β1 integrin under control of the Rab11 …

Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of
cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 …