Wolbachia as translational science: controlling mosquito-borne pathogens

EP Caragata, HLC Dutra, PHF Sucupira… - Trends in …, 2021 - cell.com
In this review we examine how exploiting the Wolbachia–mosquito relationship has become
an increasingly popular strategy for controlling arbovirus transmission. Field deployments of …

Let's get physical: flavivirus-host protein–protein interactions in replication and pathogenesis

AT Fishburn, OH Pham, MW Kenaston… - Frontiers in …, 2022 - frontiersin.org
Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …

Using Wolbachia to Eliminate Dengue: Will the Virus Fight Back?

KM Edenborough, HA Flores, CP Simmons… - Journal of …, 2021 - Am Soc Microbiol
Recent field trials have demonstrated that dengue incidence can be substantially reduced
by introgressing strains of the endosymbiotic bacterium Wolbachia into Aedes aegypti …

Wolbachia's Deleterious Impact on Aedes aegypti Egg Development: The Potential Role of Nutritional Parasitism

MJ Allman, JE Fraser, SA Ritchie, DA Joubert… - Insects, 2020 - mdpi.com
Simple Summary Mosquito-borne viral diseases such as dengue, Zika and chikungunya
cause a significant global health burden and are currently increasing in outbreak frequency …

Microbes increase thermal sensitivity in the mosquito Aedes aegypti, with the potential to change disease distributions

F Ware-Gilmore, CM Sgrò, Z Xi, HLC Dutra… - PLoS neglected …, 2021 - journals.plos.org
The mosquito Aedes aegypti is the primary vector of many disease-causing viruses,
including dengue (DENV), Zika, chikungunya, and yellow fever. As consequences of climate …

Designing effective Wolbachia release programs for mosquito and arbovirus control

PA Ross - Acta tropica, 2021 - Elsevier
Mosquitoes carrying endosymbiotic bacteria called Wolbachia are being released in
mosquito and arbovirus control programs around the world through two main approaches …

Molecular rationale of insect-microbes symbiosis—from insect behaviour to Mechanism

S Singh, A Singh, V Baweja, A Roy, A Chakraborty… - Microorganisms, 2021 - mdpi.com
Insects nurture a panoply of microbial populations that are often obligatory and exist
mutually with their hosts. Symbionts not only impact their host fitness but also shape the …

Comprehensive Quantitative Proteome Analysis of Aedes aegypti Identifies Proteins and Pathways Involved in Wolbachia pipientis and Zika Virus Interference …

M Martins, LFC Ramos, JR Murillo, A Torres… - Frontiers in …, 2021 - frontiersin.org
Zika virus (ZIKV) is a global public health emergency due to its association with
microcephaly, Guillain-Barré syndrome, neuropathy, and myelitis in children and adults. A …

Grass carp reovirus induces formation of lipid droplets as sites for its replication and assembly

L He, Q Wang, X Liang, H Wang, P Chu, C Yang, Y Li… - Mbio, 2022 - Am Soc Microbiol
Grass carp is an important commercial fish in China that is plagued by various diseases,
especially the hemorrhagic disease induced by grass carp reovirus (GCRV). Nevertheless …

Wolbachia-mediated resistance to Zika virus infection in Aedes aegypti is dominated by diverse transcriptional regulation and weak evolutionary pressures

EC Boehm, AS Jaeger, HJ Ries… - PLoS neglected …, 2023 - journals.plos.org
A promising candidate for arbovirus control and prevention relies on replacing arbovirus-
susceptible Aedes aegypti populations with mosquitoes that have been colonized by the …