▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

The Wnt family of secreted signalling molecules are essential in embryo development and
tumour formation. The Frizzled (Fz) family of serpentine receptors function as Wnt …

The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in
directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt …

LDL receptor related proteins 5 and 6 (LRP5/6) and their Drosophila homolog Arrow are
single-span transmembrane proteins essential for Wnt/β-catenin signaling, likely via acting …

Wnts are highly-conserved lipid-modified secreted proteins that activate multiple signaling
pathways. These pathways regulate crucial processes during various stages of development …

Communication between cells is often mediated by secreted signaling molecules that bind
cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt …

Wnts are secreted proteins that are essential for a wide array of developmental and
physiological processes. They signal across the plasma membrane by interacting with …