For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Background Precision medicine, space exploration, drug discovery to characterization of
dark chemical space of habitats and organisms, metabolomics takes a centre stage in …

Progress in mass spectrometry lipidomics has led to a rapid proliferation of studies across
biology and biomedicine. These generate extremely large raw datasets requiring …

Lipidomics studies suffer from analytical and annotation challenges because of the great
structural similarity of many of the lipid species. To improve lipid characterization and …

Sortilin has been positively correlated with vascular disorders in humans. No study has yet
evaluated the possible direct effect of sortilin on vascular function. We used pharmacological …

Ceramides are essential precursors of complex sphingolipids and act as potent signaling
molecules. Ceramides are synthesized in the endoplasmic reticulum (ER) and receive their …

The implication of lipid dysregulation in diseases, toxic exposure outcomes, and
inflammation has brought great interest to lipidomic studies. However, lipids have proven to …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes
with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid …

A causal relationship between plasma ceramide concentration and respiratory distress
symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals …