Background Most strokes are due to blockage of an artery in the brain by a blood clot.
Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage …

Intracerebral haemorrhage is a complication of thrombolytic therapy for acute myocardial
infarction, pulmonary embolism, and ischaemic stroke. There is increasing evidence that …

ContextControversy and uncertainty ensue when the results of clinical research on the
effectiveness of interventions are subsequently contradicted. Controversies are most …

Active-control noninferiority trials are being performed with increasing frequency when
standard placebo-controlled trials are considered unethical. Three attributes are optimally …

Background and Purpose—Efforts to increase the availability and shorten the time delivery
of intravenous thrombolysis in patients with acute ischemic stroke carry the potential for …

Background Fibrinolytic therapy offers an alternative to mechanical reperfusion for ST-
segment elevation myocardial infarction (STEMI) in settings where health-care resources …

Thrombosis, the blockage of blood vessels with clots, can lead to acute myocardial infarction
and ischemic stroke, both leading causes of death. Other than surgical interventions to …

Systemic Thrombolysis for Pulmonary Embolism: A Review - PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main …

INTRODUCTION: Ultrasound (US)-enhanced thrombolytic treatment protocols currently in
clinical trials for stroke applications involve systemic administration of tissue plasminogen …

Background: Plasminogen is the zymogen form of plasmin and the precursor of angiostatin.
It has been implicated in a variety of disease states, including thrombosis, bleeding and …