Nonlinear mixed effects models have become a standard platform for analysis when data is
in the form of continuous and repeated measurements of subjects from a population of …

Optimization of clinical trial designs can help investigators achieve higher quality results for
the given resource constraints. The present paper gives an overview of optimal designs for …

Root exudates are an important pathway for plant–microbial interactions and are highly
sensitive to climate change. However, how extreme drought affects root exudates and the …

Background Obesity is one of the most prevalent somatic comorbidities of Major Depressive
Disorder (MDD). We aimed to investigate the relationship between body mass index (BMI) …

Root exudates determine plant's ability to acquire nutrients through influencing plant's
interactions with soil microorganisms. Recent studies suggest that plant's associations with …

We present a Bayesian nonlinear mixed-effects location scale model (NL-MELSM). The NL-
MELSM allows for fitting nonlinear functions to the location, or individual means, and the …

Variability is an intrinsic property of biological systems and is often at the heart of their
complex behaviour. Examples range from cell-to-cell variability in cell signalling pathways to …

Pheromone traps are widely used for monitoring or managing insect pest populations.
However, it is important to know their range of attraction to optimize the setting of pheromone …

Background Oscillatory activity in the subthalamic nucleus (STN) in Parkinson's disease
(PD) is under extensive study. While rhythmic features of local field potentials are implicated …

Receiving a healthy amount of sleep is essential to one's quality of life. Both sleep-wake
timing preferences (chronotype) and sleep duration are implicated in health, academic …