Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
Impact of binding site comparisons on medicinal chemistry and rational molecular design
C Ehrt, T Brinkjost, O Koch - Journal of medicinal chemistry, 2016 - ACS Publications
Modern rational drug design not only deals with the search for ligands binding to interesting
and promising validated targets but also aims to identify the function and ligands of yet …
and promising validated targets but also aims to identify the function and ligands of yet …
Protein function prediction: towards integration of similarity metrics
Genomic centers discover increasingly many protein sequences and structures, but not
necessarily their full biological functions. Thus, currently, less than one percent of proteins …
necessarily their full biological functions. Thus, currently, less than one percent of proteins …
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
Abstract Gene3D http://gene3d. biochem. ucl. ac. uk is a comprehensive database of protein
domain assignments for sequences from the major sequence databases. Domains are …
domain assignments for sequences from the major sequence databases. Domains are …
Genome-wide identification of ascorbate peroxidase (APX) gene family and the function of SmAPX2 under high temperature stress in eggplant
L Shen, Y Zhou, X Yang - Scientia Horticulturae, 2024 - Elsevier
Ascorbate peroxidase (APX) plays pivotal roles in regulating diverse biological processes in
plants against biotic and abiotic stresses by eliminating hydrogen peroxide (H 2 O 2) …
plants against biotic and abiotic stresses by eliminating hydrogen peroxide (H 2 O 2) …
Identification and Characterization of the APX Gene Family and Its Expression Pattern under Phytohormone Treatment and Abiotic Stress in Populus trichocarpa
X Leng, H Wang, S Zhang, C Qu, C Yang, Z Xu, G Liu - Genes, 2021 - mdpi.com
Ascorbate peroxidase (APX) is a member of class I of the heme-containing peroxidase
family. The enzyme plays important roles in scavenging reactive oxygen species for …
family. The enzyme plays important roles in scavenging reactive oxygen species for …
Engagement of intrinsic disordered proteins in protein–protein interaction
I Roterman, K Stapor, L Konieczny - Frontiers in Molecular …, 2023 - frontiersin.org
Proteins from the intrinsically disordered group (IDP) focus the attention of many researchers
engaged in protein structure analysis. The main criteria used in their identification are lack of …
engaged in protein structure analysis. The main criteria used in their identification are lack of …
DNN-m6A: a cross-species method for identifying RNA N6-methyladenosine sites based on deep neural network with multi-information fusion
As a prevalent existing post-transcriptional modification of RNA, N6-methyladenosine (m6A)
plays a crucial role in various biological processes. To better radically reveal its regulatory …
plays a crucial role in various biological processes. To better radically reveal its regulatory …
Evolutionary trace for prediction and redesign of protein functional sites
The evolutionary trace (ET) is the single most validated approach to identify protein
functional determinants and to target mutational analysis, protein engineering and drug …
functional determinants and to target mutational analysis, protein engineering and drug …
Prediction of detailed enzyme functions and identification of specificity determining residues by random forests
C Nagao, N Nagano, K Mizuguchi - PloS one, 2014 - journals.plos.org
Determining enzyme functions is essential for a thorough understanding of cellular
processes. Although many prediction methods have been developed, it remains a significant …
processes. Although many prediction methods have been developed, it remains a significant …