Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …

Chromatin-remodelling complexes of the SWI/SNF family function in the formation of
nucleosome-depleted, transcriptionally active promoter regions (NDRs),. In the yeast …

Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

Transcription initiation by RNA polymerase II (RNA Pol II) requires preinitiation complex
(PIC) assembly at gene promoters. In the dynamic nucleus, where thousands of promoters …

Precise nucleosome organization at eukaryotic promoters is thought to be generated by
multiple chromatin remodeler (CR) enzymes and to affect transcription initiation. Using an …

The classic view of nucleosome organization at active promoters is that two well-positioned
nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been …

Sophisticated gene-regulatory mechanisms probably evolved in prokaryotes billions of
years before the emergence of modern eukaryotes, which inherited the same basic …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …