Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but
their dose-effects are unclear. Therefore, we conducted a systematic review and dose …

Abstract Sodium-glucose co-transporter-2 inhibitors (SGLT2-Is) have consistently
demonstrated a clinically significant reduction of cardiovascular mortality. However, their …

Objective We aimed at testing if a correlation between adverse drug reactions relative risks
estimated from meta-analyses and disproportionality analyses calculated from …

Clinical evaluation of drugs before approval is based on the experimental design of clinical
trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are …

Introduction Impulse control disorders (eg pathological gambling, hypersexuality) may
develop as adverse reactions to drugs. Pathogenetic hypotheses have mainly focused on …

Background Hyponatraemia induced by antidepressant drugs is a rare but potentially life-
threatening adverse reaction. Whether it is associated with all or only some antidepressant …

This chapter aims to describe current and emerging roles of spontaneous reporting systems
(SRSs) for assessing and monitoring drug safety. Moreover, it offers a perspective on the …

In pharmacovigilance, disproportionality analyses based on individual case safety reports
are widely used to detect safety signals. Unfortunately, publishing disproportionality …

Abstract Background and Aim Disproportionality analysis is traditionally used in
spontaneous reporting systems to generate working hypotheses about potential adverse …

Aims Recent data suggest that antidepressants are associated with incident diabetes but the
possible pharmacological mechanism is still questioned. The aim of the present study was to …