Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …

The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

The TFCP2/Grainyhead family of transcription factors is divided into two distinct subfamilies,
one of which includes the Grainyhead-like 1-3 (GRHL1-3) proteins and the other consists of …

During embryonic development, naive pluripotent epiblast cells transit to a formative state.
The formative epiblast cells form a polarized epithelium, exhibit distinct transcriptional and …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …

In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative
pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells …

Estrogen‐related receptor b (Esrrb) is part of a family of three orphan nuclear receptors with
broad expression profiles and a generic function in regulating energy metabolism in …

Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-
R), but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are …

To reveal how cells exit human pluripotency, we designed a CRISPR-Cas9 screen
exploiting the metabolic and epigenetic differences between naïve and primed pluripotent …

Primed epiblast stem cells (EpiSCs) can be reverted to a pluripotent embryonic stem cell
(ESC)-like state by expression of single reprogramming factor. We used CRISPR activation …