Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …

Obesity is characterized by an increase in body weight associated with an exaggerated
enlargement of the adipose tissue. Obesity has serious negative effects because it is …

Dyslipidemia and insulin resistance are commonly associated with catabolic or
lipodystrophic conditions (such as cancer and sepsis) and with pathological states of …

Traditional diagnosis and understanding of the pathophysiology of obesity are based on
excessive fat storage due to a chronically positive energy balance characterized by body …

Recent studies associate obesity and insulin resistance in horses with development of
abnormal reproductive function and debilitating laminitis. The factors contributing to insulin …

Aims/hypothesis Clear evidence exists that TNF-α inhibits insulin signalling and thereby
glucose uptake in myocytes and adipocytes. However, conflicting results exist with regard to …

The adipose tissue has been recognized as an active organ involved in numerous
metabolic, hormonal and immunological processes. Obesity and associated chronic …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …