Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as
important regulators of gene expression. Here, we investigated the function and molecular …

Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …

In order to generate a zebrafish model of β cell regeneration, we have expressed an
Escherichia coli gene called nfsB in the β cells of embryonic zebrafish. This bacterial gene …

Background—Cardiac cachexia is characterized by an exaggerated loss of skeletal muscle,
weakness, and exercise intolerance, although the cause of these effects remains unknown …

The discovery of myostatin and our introduction to the “Mighty Mouse” over a decade ago
spurred both basic and applied research and impacted popular culture as well. The …

The loss in muscle mass coupled with a decrease in specific force and shift in fiber
composition are hallmarks of aging. Training and regular exercise attenuate the signs of …

Through the use of stem cell-derived cardiac myocytes, tissue-engineered human
myocardial constructs are poised for modeling normal and diseased physiology of the heart …

A finite number of transcription factors constitute a combinatorial code that orchestrates
cardiac development and the specification and differentiation of myocytes. Many, if not all of …