Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Background Cholangiocarcinomas are a heterogeneous group of malignancies arising from
a number of cells of origin along the biliary tree. Although most cases in Western countries …

Acute inflammation is a response to an alteration induced by a pathogen or a physical or
chemical insult, which functions to eliminate the source of the damage and restore …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Hepatocellular carcinoma (HCC) is an aggressive malignancy mainly due to metastases or
postsurgical recurrence. We postulate that metastases are influenced by the liver …

During sepsis, the liver plays a key role. It is implicated in the host response, participating in
the clearance of the infectious agents/products. Sepsis also induces liver damage through …

Background & Aims: Because the mechanisms leading to bile duct damage in sclerosing
cholangitis are unknown, we aimed to determine the pathogenesis of bile duct injury in …

Primary biliary cirrhosis (PBC) is a chronic inflammatory autoimmune disease that mainly
targets the cholangiocytes of the interlobular bile ducts in the liver. The condition primarily …

Chronic cholestasis and liver inflammation are the two main pathophysiological components
of the two major classes of disease–primary biliary cirrhosis (PBC) and primary sclerosing …