Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs | New England
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The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in
physiology by its ability to directly regulate the immunosuppressive actions of …

Glucocorticoids (GCs) are steroid hormones produced by the adrenal gland and regulated
by the hypothalamus‐pituitary‐adrenal axis. GCs mediate effects that mostly result in …

The glucocorticoids are the most potent anti‐inflammatory drugs that we possess and are
effective in a wide variety of diseases. Although their action is known to involve receptor …

Macrophages were first described as phagocytic immune cells responsible for maintaining
tissue homeostasis by the removal of pathogens that disturb normal function. Historically …

Cytosolic phospholipase A2a (cPLA2a) preferentially hydrolyzes phospholipids containing
arachidonic acid and plays a key role in the biosynthesis of eicosanoids. This review …

Phagocytic clearance of apoptotic leukocytes plays an important role in the resolution of
inflammation. The glucocorticoid-inducible protein annexin 1 and annexin 1-derived …

Abstract Objective Annexin 1 (Anx‐1) is a putative mediator of the antiinflammatory actions
of glucocorticoids (GCs). This study investigated the role of Anx‐1 in experimental arthritis …

Chemoresistance is a major therapeutic obstacle in cancer patients, and the mechanisms of
drug resistance are not fully understood. In the present study, we established platinum …

The postnatal development of Leydig cells can be divided into three distinct stages: initially
they exist as fibroblast-like progenitor Leydig cells (PLCs) appearing in the testis by Days 14 …