[HTML][HTML] Leptin increases hepatic triglyceride export via a vagal mechanism in humans

M Metz, M Beghini, P Wolf, L Pfleger, M Hackl… - Cell metabolism, 2022 - cell.com
Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with
lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative …

INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis

M Gajdošík, K Landheer, KM Swanberg, C Juchem - Scientific reports, 2021 - nature.com
In vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research
and clinical diagnostics, allowing for non-invasive measurement and analysis of small …

Gluconeogenesis, but not glycogenolysis, contributes to the increase in endogenous glucose production by SGLT-2 inhibition

P Wolf, P Fellinger, L Pfleger, H Beiglböck… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE Recent studies indicate that sodium-glucose cotransporter 2 (SGLT-2) inhibition
increases endogenous glucose production (EGP), potentially counteracting the glucose …

Non-invasive analysis of human liver metabolism by magnetic resonance spectroscopy

JG Jones - Metabolites, 2021 - mdpi.com
The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal
site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations …

[HTML][HTML] Increased ATP synthesis might counteract hepatic lipid accumulation in acromegaly

P Fellinger, P Wolf, L Pfleger, P Krumpolec, M Krssak… - JCI insight, 2020 - ncbi.nlm.nih.gov
Patients with active acromegaly (ACRO) exhibit low hepatocellular lipids (HCL), despite
pronounced insulin resistance (IR). This contrasts the strong association of IR with …

In Vitro 31P MR Chemical Shifts of In Vivo-Detectable Metabolites at 3T as a Basis Set for a Pilot Evaluation of Skeletal Muscle and Liver 31P Spectra with LCModel …

P Sedivy, T Dusilova, M Hajek, M Burian, M Krššák… - Molecules, 2021 - mdpi.com
Most in vivo 31P MR studies are realized on 3T MR systems that provide sufficient signal
intensity for prominent phosphorus metabolites. The identification of these metabolites in the …

Reproducibility of absolute quantification of adenosine triphosphate and inorganic phosphate in the liver with localized 31P‐magnetic resonance spectroscopy at 3‐T …

M Jonuscheit, S Wierichs, M Rothe… - NMR in …, 2024 - Wiley Online Library
Concentrations of the key metabolites of hepatic energy metabolism, adenosine
triphosphate (ATP) and inorganic phosphate (Pi), can be altered in metabolic disorders such …

Increased GH/IGF-I axis activity relates to lower hepatic lipids and phosphor metabolism

P Fellinger, H Beiglböck, G Semmler… - The Journal of …, 2023 - academic.oup.com
Context Non-alcoholic fatty liver disease (NAFLD) is a leading causes of liver-related
morbidity and mortality. While data on acromegaly, a state of chronic growth hormone …

Potential role of skeletal muscle glycerophosphocholine in response to altered fluid balance in humans: an in vivo nuclear magnetic resonance study

C Baumgartner, P Wolf, H Beiglböck… - American Journal …, 2023 - journals.physiology.org
Many cells adapt to hyperosmolal conditions by upregulation of organic osmolytes to
maintain cell function and integrity. Glycerophosphocholine (GPC), a recognized osmolyte in …

Concentration of Gallbladder Phosphatidylcholine in Cholangiopathies: A Phosphorus‐31 Magnetic Resonance Spectroscopy Pilot Study

L Pfleger, E Halilbasic, M Gajdošík… - Journal of Magnetic …, 2022 - Wiley Online Library
Background Biliary phosphatidylcholine (PtdC) concentration plays a role in the
pathogenesis of bile duct diseases. In vivo phosphorus‐31 magnetic resonance …