The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including
diabetic retinopathy and nephropathy). Cognitive impairment is a well-known complication …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …

Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by
endogenously released 'endocannabinoids' or exogenously administered compounds in a …

Neuroinflammation plays a key role in the pathogenesis of Parkinson's disease (PD).
Epidemiologic, animal, human, and therapeutic studies support the role of oxidative stress …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Cannabinoids, the active components of cannabis (Cannabis sativa) extracts, have attracted
the attention of human civilizations for centuries, much earlier than the discovery and …

Blood–brain barrier (BBB) pathology leads to neurovascular disorders and is an important
target for therapies. However, the study of BBB pathology is difficult in the absence of …