[HTML][HTML] Magnetic iron oxide nanoparticles for brain imaging and drug delivery
Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …
Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Delivering the promise of gene therapy with nanomedicines in treating central nervous system diseases
Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …
Recent advances on ultrasound contrast agents for blood-brain barrier opening with focused ultrasound
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery.
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …
Nanomaterials for Parkinson disease: Recent progress
Even though Parkinson's disease (PD) is the second most common neurological disorder
(ND), it faces an absence of credible drug delivery, treatment and diagnosis. Levodopa is …
(ND), it faces an absence of credible drug delivery, treatment and diagnosis. Levodopa is …
A novel fluorinated polyethyleneimine with microRNA-942-5p-sponges polyplex gene delivery system for non-small-cell lung cancer therapy
Y Jin, W Yu, W Zhang, C Wang, Y Liu, WE Yuan… - Journal of Colloid and …, 2023 - Elsevier
Gene delivery for non-small-cell lung cancer treatment has been a challenge due to low
nucleic acid binding ability, cell-wall barrier, and high cytotoxicity. Cationic polymers, such …
nucleic acid binding ability, cell-wall barrier, and high cytotoxicity. Cationic polymers, such …
Mechanistic insights, treatment paradigms, and clinical progress in neurological disorders: current and future prospects
Neurodegenerative diseases (NDs) are a major cause of disability and are related to brain
development. The neurological signs of brain lesions can vary from mild clinical shortfalls to …
development. The neurological signs of brain lesions can vary from mild clinical shortfalls to …
[HTML][HTML] The relationship between surface drug distribution of Dox-loaded microbubbles and drug release/cavitation behaviors with ultrasound
Abstract Ultrasound (US)-triggered microbubbles (MBs) drug delivery is a promising tool for
noninvasive and localized therapy. Several studies have shown the potential of drug-loaded …
noninvasive and localized therapy. Several studies have shown the potential of drug-loaded …
Nanoparticles as drug delivery systems of RNAi in cancer therapy
D Li, C Gao, M Kuang, M Xu, B Wang, Y Luo, L Teng… - Molecules, 2021 - mdpi.com
RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a
target gene via cellular machinery with much higher efficiency in contrast to other antisense …
target gene via cellular machinery with much higher efficiency in contrast to other antisense …
Nanoplatform‐based in vivo gene delivery systems for cancer therapy
R Luo, H Le, Q Wu, C Gong - Small, 2024 - Wiley Online Library
Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …